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A Comprehensive Review on the Therapeutic Versatility of Imidazo [2,1-b]- thiazoles

Author(s):

Mohd Adil Shareef, Irfan Khan, Bathini Nagendra Babu and Ahmed Kamal*   Pages 1 - 24 ( 24 )

Abstract:


Background: Imidazo[2,1-b]thiazole, a well known fused five-membered hetrocycle is one of the most promising and versatile moieties in the area of medicinal chemistry. Derivatives of imidazo[2,1-b]thiazole have been investigated for the development of new derivatives that exhibit diverse pharmacological activities. This fused heterocycle is also a part of a number of therapeutic agents.

Objective: To review the extensive pharmacological activities of imidazo[2,1-b]thiazole derivatives and the new molecules developed between 2000-2018 and their usefulness.

Method: Thorough literature review of all relevant papers and patents was conducted.

Conclusion: The present review, covering a number of aspects, is expected to provide useful insights in the design of imidazo[2,1-b]thiazole-based compounds and would inspire the medicinal chemists for a comprehensive and target-oriented information to achieve a major breakthrough in the development of clinically viable candidates.

Keywords:

Imidazo[2, 1-b]-thiazoles, pharmacological activities, therapeutic versatility, cytotoxic, antimicrobial.

Affiliation:

Department of Fluoro-Agrochemicals, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad, Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, Department of Fluoro-Agrochemicals, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad, Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002



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