Mohd Adil Shareef, Irfan Khan, Bathini Nagendra Babu and Ahmed Kamal* Pages 1 - 24 ( 24 )
Background: Imidazo[2,1-b]thiazole, a well known fused five-membered hetrocycle is one of the most promising and versatile moieties in the area of medicinal chemistry. Derivatives of imidazo[2,1-b]thiazole have been investigated for the development of new derivatives that exhibit diverse pharmacological activities. This fused heterocycle is also a part of a number of therapeutic agents.Objective: To review the extensive pharmacological activities of imidazo[2,1-b]thiazole derivatives and the new molecules developed between 2000-2018 and their usefulness. Method: Thorough literature review of all relevant papers and patents was conducted. Conclusion: The present review, covering a number of aspects, is expected to provide useful insights in the design of imidazo[2,1-b]thiazole-based compounds and would inspire the medicinal chemists for a comprehensive and target-oriented information to achieve a major breakthrough in the development of clinically viable candidates.
Imidazo[2, 1-b]-thiazoles, pharmacological activities, therapeutic versatility, cytotoxic, antimicrobial.
Department of Fluoro-Agrochemicals, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad, Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002, Department of Fluoro-Agrochemicals, CSIR-Indian Institute of Chemical Technology, Tarnaka, Hyderabad, Academy of Scientific and Innovative Research (AcSIR), Ghaziabad 201002