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Role of Exosomes in Photodynamic Anticancer Therapy

Author(s):

Yuan Jiang, Chuanshan Xu*, Wingnang Leung*, Mei Lin, Xiaowen Cai, Huanhuan Guo, Jiyong Zhang and Fanwen Yang   Pages 1 - 9 ( 9 )

Abstract:


Photodynamic therapy (PDT) is a promising alternative treatment for malignancies basing on photochemical reaction induced by photosensitizers (PS) under light irradiation. Recent studies show that PDT caused abundant release of exosomes from tumor tissues. It is well-known that exosomes as carriers play an important role in cell-cell communication through transporting many kinds of bioactive molecules (e.g. lipids, proteins, mRNA, miRNA and lncRNA). Therefore, to explore the role of exosomes in photodynamic anticancer therapy has been attracting extensive attention. In the present paper, we will briefly introduce the basic principle of PDT and exosomes, and focus on discussing the role of exosomes in photodynamic anticancer therapy, to further enrich and boost the development of PDT.

Keywords:

Photodynamic therapy, tumor, exosomes, tumor microenvironment, tumor metastasis, tumor drug resistance

Affiliation:

Key Laboratory of Molecular Target and Clinical Pharmacology, State Key Laboratory of Respiratory Disease, School of Pharmaceutical Science & Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, 511436, Key Laboratory of Molecular Target and Clinical Pharmacology, State Key Laboratory of Respiratory Disease, School of Pharmaceutical Science & Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, 511436, Division of Chinese Medicine, School of Professional and Continuing Education, The University of Hong Kong, Key Laboratory of Molecular Target and Clinical Pharmacology, State Key Laboratory of Respiratory Disease, School of Pharmaceutical Science & Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, 511436, Key Laboratory of Molecular Target and Clinical Pharmacology, State Key Laboratory of Respiratory Disease, School of Pharmaceutical Science & Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, 511436, Key Laboratory of Molecular Target and Clinical Pharmacology, State Key Laboratory of Respiratory Disease, School of Pharmaceutical Science & Fifth Affiliated Hospital, Guangzhou Medical University, Guangzhou, Guangdong, 511436, Department of Biomedical Engineering, School of Basic Medical Sciences, Guangzhou Medical University, Guangzhou, Guangdong, 511436, Shenzhen Maternity and Child Health Care Hospital, Shenzhen, 518017, China; eDepartment of Rehabilitation Medicine, the First Affiliated Hospital of Chengdu Medical College, Chengdu, 610500



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