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The Haywain: Anti-synthetase Antibodies in Patients with Inflammatory Diseases: Targeting Monocytes or Neutrophils?

Author(s):

Bob Meek and Ger Rijkers *   Pages 1 - 9 ( 9 )

Abstract:


Autoantibiodies against aminoacyl-tRNA synthetases are found in patients suffering from a wide range of autoimmune and inflammatory disorders. Recent data indicate that these antibodies are directed against splice-variants of synthetase genes, the so-called catalytic nulls. Latter molecules have cytokine-like functions and are involved in the regulation of the activation of lymphocytes, monocytes and granulocytes. The potential role of anti-synthetase antibodies as a diagnostic tool and a target for therapeutic interventions is discussed.

Keywords:

Anti-Synthetase, Dermatomyositis, Polymyositis, Interstitial Lung Disease

Affiliation:

Laboratory for Medical Microbiology and Immunology, St Antonius Hospital Nieuwegein, Middelburg, Laboratory for Medical Microbiology and Immunology, St Antonius Hospital Nieuwegein



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