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Resveratrol: A New Potential Therapeutic Agent for Melanoma?

Author(s):

Mohamad Hossein Pourhanifeh, Kazem Abbaszadeh-Goudarzi, Mohammad Goodarzi, Sara G.M. Piccirillo, Alimohammad Shafiee, Sarah Hajighadimi, Sanaz Moradizarmehri, Zatollah Asemi* and Hamed Mirzaei*   Pages 1 - 25 ( 25 )

Abstract:


Melanoma is the most life-threatening and aggressive class of skin malignancies. The incidence of melanoma has steadily increased. Metastatic melanoma is greatly resistant to standard anti-melanomatreatments such as chemotherapy, and 5-year survival rate of cases with melanoma who have metastatic form of disease is less than 10%. The contributing role of apoptosis, angiogenesis and autophagy in the pathophysiology of melanoma has been previously demonstrated. Thus, it is extremely urgent to search for complementary therapeutic approachesthat couldenhance the quality of life of subjects and reduce treatment resistance and adverse effects. Resveratrol, known as a polyphenol component present in grapes and some plants, has anti-cancer properties due to its function as an apoptosis inducer in tumor cells, and anti-angiogenic agent to prevent metastasis. However, more clinical trials should be conducted to prove resveratrol efficacy.

Herein, for first time, we summarize current knowledge of anti-cancerous activities of resveratrol in melanoma.

Keywords:

Melanoma, Resveratrol, Therapy, Natural compounds, Apoptosis, Angiogenesis

Affiliation:

Halal Research Center of IRI, FDA, Tehran, Cellular and Molecular Research Center, Department of Biochemistry and Nutrition, Sabzevar University of Medical Sciences, Sabzevar, Department of Biochemistry, University of Texas Southwestern Medical Center, Dallas, TX 75390, Division of Hematology and Oncology, Department of Internal Medicine, University of Texas Southwestern Medical Center, Dallas, Texas 75390, Division of General Internal Medicine, Toronto General Hospital, Toronto, Division of General Internal Medicine, Toronto General Hospital, Toronto, Division of General Internal Medicine, Toronto General Hospital, Toronto, Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Research Center for Biochemistry and Nutrition in Metabolic Diseases, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan



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