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Biosynthesized Quantum Dots as Improved Biocompatible Tools for Biomedical Applications

Author(s):

Keru Shi, Xinyi Xu, Hanrui Li, Hui Xie, Xueli Chen and Yonghua Zhan*   Pages 1 - 17 ( 17 )

Abstract:


Quantum dots (QDs), whose diameters are often limited to 10 nm, have been of interest to researchers for their unique optical characteristics, which are attributed to quantum confinement. Following their early application in the electrical industry as light-emitting diode materials, semiconductor nanocrystals have continued to show great potential in clinical diagnosis and biomedical applications. The conventional physical and chemical pathways for QD syntheses typically require harsh conditions and hazardous reagents, and these products encounter non-hydrophilic problems due to organic capping ligands when they enter the physiological environment. The natural reducing abilities of living organisms, especially microbes, are then exploited to prepare QDs from available metal precursors. Low-cost and eco-friendly biosynthesis approaches have the potential for further biomedical applications which benefit from the good biocompatibility of protein-coated QDs. The surface biomass offers many binding sites for modifying substances or targeting ligands and so achieving multiple functions through simple and efficient operations. Biosynthetic QDs could function as bioimaging and biolabeling agents because of their luminescence properties similar to those of chemical QDs. In addition, extensive research has been carried out on the antibacterial activity, metal ion detection and bioremediation. As a result, this review details the advanced progress of biomedical applications of biosynthesized QDs and illustrates these principles as clearly as possible.

Keywords:

Quantum Dot, Biosynthesis, Biocompatibility, Biomedical Application, Photoelectrochemical, Bioimaging, Microorganism

Affiliation:

Engineering Research Center of Molecular and Neuro Imaging of the Ministry of Education, School of Life Science and Technology, Xidian University, Xi’an, Shaanxi, 710071, Engineering Research Center of Molecular and Neuro Imaging of the Ministry of Education, School of Life Science and Technology, Xidian University, Xi’an, Shaanxi, 710071, Engineering Research Center of Molecular and Neuro Imaging of the Ministry of Education, School of Life Science and Technology, Xidian University, Xi’an, Shaanxi, 710071, Engineering Research Center of Molecular and Neuro Imaging of the Ministry of Education, School of Life Science and Technology, Xidian University, Xi’an, Shaanxi, 710071, Engineering Research Center of Molecular and Neuro Imaging of the Ministry of Education, School of Life Science and Technology, Xidian University, Xi’an, Shaanxi, 710071, Engineering Research Center of Molecular and Neuro Imaging of the Ministry of Education, School of Life Science and Technology, Xidian University, Xi’an, Shaanxi, 710071



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