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1-Deoxynojirimycin and its Derivatives: A Mini Review of the Literature

Author(s):

Haijun Wang, Yin Shen, Lei Zhao* and Youfan Ye   Pages 1 - 15 ( 15 )

Abstract:


1-Deoxynojirimycin (1-DNJ) is a naturally occurred sugar analogue with unique bioactivities. It was found in mulberry leaves and silkworms, as well as in the metabolites of certain microorganisms, including Streptomyces and Bacillus. 1-DNJ is a potent α-glucosidase inhibitor and it possesses anti-hyperglycemic, anti-obese, anti-viral and anti-tumor features. Some derivatives of 1-DNJ, like miglitol, miglustat and migalastat, were applied clinically to treat diseases such as diabetes and lysosomal storage disorders. The present review focused on the extraction, determination, pharmacokinetics and bioactivity of 1-DNJ, as well as the clinical application of 1-DNJ derivatives.

Keywords:

1-deoxynojirimycin, miglitol, miglustat, imino sugars, glucosidase inhibitors

Affiliation:

Department of Neurosurgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, Department of Neurosurgery, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, Department of Infectious Disease, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei, Department of Ophthalmology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan, Hubei



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