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Antibacterial Agents Targeting the Bacterial Cell Wall

Author(s):

Li Shan , Qin Wenling*, Panunzio Mauro and Biondi Stefano   Pages 1 - 24 ( 24 )

Abstract:


The introduction of antibiotics to treat bacterial infections either by killing or blocking their growth has been accompanied by the studies of mechanism that allows the drugs to kill the bacteria or to stop their proliferation. In such scenario the coming of antibacterial agents active on the bacterial cell wall has been of fundamental importance in the fight against bacterial agents responsible for severe diseases. As a matter of fact cell wall, that plays many roles during lifecycle, is an essential constituent of most bacteria. This overview focus on the intracellular steps of peptidoglycan biosynthesis and the research of new antibacterial agents based on the enzymes involved in these early steps of the formation of cell membrane components.

Keywords:

Antibiotics, Bacterial cell wall, Peptidoglycan, Murein enzymes, Review

Affiliation:

Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, School of Pharmaceutical Sciences, Chongqing University, 401331, Chongqing, Chongqing Key Laboratory of Natural Product Synthesis and Drug Research, School of Pharmaceutical Sciences, Chongqing University, 401331, Chongqing, Isof-CNR Chemistry Department, Via Selmi, 2, 40126 Bologna , BioVersys AG, C/o Technologiepark Basel, Hochbergerstrasse 60c, CH-4057 Basel



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