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The Emerging Role of Atrial Natriuretic Peptide in Psychiatry

Author(s):

Donatella Marazziti, Filippo Maria Barberi, Federico Mucci*, Alessandra Maglio, Valerio Dell’Oste and Liliana Dell’Osso   Pages 1 - 10 ( 10 )

Abstract:


Introduction: Atrial natriuretic peptide (ANP), composed by 28 amino acids, is well known to modulate fluid and electrolyte homeostasis, the hypothalamic-pituitary-adrenal (HPA) axis activity and the immune system. Since ANP is produced in both heart and in the central nervous system, in the last years, an increasing attention has been devoted to its possible role in neuropsychiatric disorders. Indeed, scattered data would indicate its possible role in anxiety, major depression, addictive behaviours, post-traumatic stress disorder and other stress-related disorders. Further, ANP has been hypothesized to represent one of the factors linking depression to cardiovascular health and immune system.

Aims: Given the paucity of available information, the aim of this paper was at reviewing the current literature on the role of ANP in the central nervous system (CNS), and in the pathophysiology of different neuropsychiatric and stress-related conditions.

Discussion: Supporting data on ANP in psychiatric disorders are still limited to animal studies, or to a few “real” data in patients gathered some decades ago that should be replicated in larger clinical samples.

Conclusions: Further studies are necessary to understand the possible implications of ANP in neuropsychiatry, because potentially it might represent a new way for really innovative psychopharmacological treatments in different conditions all underlined by hyperactive HPA axis.

Keywords:

Atrial natriuretic peptide, depression, anxiety disorder, post-traumatic stress disorder, schizophrenia, alcohol abuse  

Affiliation:

Dipartimento di Medicina Clinica e Sperimental, Section of Psychiatry, University of Pisa, Dipartimento di Medicina Clinica e Sperimental, Section of Psychiatry, University of Pisa, Dipartimento di Medicina Clinica e Sperimental, Section of Psychiatry, University of Pisa, Dipartimento di Medicina Clinica e Sperimental, Section of Psychiatry, University of Pisa, Dipartimento di Medicina Clinica e Sperimental, Section of Psychiatry, University of Pisa, Dipartimento di Medicina Clinica e Sperimental, Section of Psychiatry, University of Pisa



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