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Discovery of Anticancer Agents from 2-Pyrazoline-Based Compounds

Author(s):

Qing-Shan Li*, Bang-Nian Shen, Zhen Zhang, Ban-Feng Ruan and Shuying Luo   Pages 1 - 23 ( 23 )

Abstract:


As nitrogen-containing five-membered heterocyclic structural units, the substituted pyrazole derivatives have broad spectrum of pharmacological activities, especially 4,5-dihydro-1H-pyrazoles that also commonly known as 2-pyrazolines. Since 2010, considerable studies have been found that the 2-pyrazoline derivatives possess potent anticancer activities. In present review, it covers the pyrazoline derivatives reported by literatures from 2010 till date (2010-2019). This review aims to establish the relationship between the anticancer activities variation and different substituents introduced into 2-pyrazoline core, which could provide important pharmacophore clues for the discovery of new anticancer agents that containing 2-pyrazoline scaffold.

Keywords:

2-pyrazoline, 4 5-dihydro-1H-pyrazole, derivatives, anticancer activities, synthesis, SAR

Affiliation:

Hefei University of Technology, School of Food and Biological Engineering, Hefei University of Technology, School of Food and Biological Engineering, Hefei University of Technology, School of Food and Biological Engineering, Hefei University of Technology, School of Food and Biological Engineering, Henan provincial key laboratory of children’s genetics and metabolic diseases, Children’s Hospital Affiliated to Zhengzhou University, Zhengzhou University, Zhengzhou,450018



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