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Nitric Oxide and Hydrogen Sulfide: A Nice Pair in the Respiratory System


Salvatore Fuschillo, Letizia Palomba, Rosanna Capparelli, Andrea Motta and Mauro Maniscalco*   Pages 1 - 13 ( 13 )


Nitric oxide (NO) is internationally regarded as a signal molecule involved in a several functions in respiratory tract under physiological and pathogenic conditions. Hydrogen sulfide (H2S) has also recently been recognized as a new gasotransmitter with a diverse range of functions similar to those of NO. Depending on their respective concentrations, both molecules act synergistically or antagonistically as signals or damage promoters. Nevertheless, available evidence shows that the complex biological connections between NO and H2S involve multiple pathways and depend on the site of action, as well as on experimental conditions. This review will provide an update on these two gasotransmitters in physiological and pathological processes also focusing on the respiratory system.


nitric oxide, H2S, biomarkers, outcome, disability, asthma, copd


Pulmonary rehabilitation Unit, ICS Maugeri, Department of Biomolecular Sciences, University of Urbino, Department of Agriculture, University of Naples “Federico II”, Institute of Biomolecular Chemistry, National Research Council, Pulmonary Rehabilitation Unit, ICS Maugeri

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