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Repurposing Antihypertensive Drugs for the Management of Alzheimer’s Disease

Author(s):

Keng Yoon Yeong* and Christine Law   Pages 1 - 15 ( 15 )

Abstract:


Alzheimer’s disease (AD) is a neurodegenerative disorder that has affected millions of people worldwide. However, currently there is no treatment to cure the disease. The AD drugs available in the market only manage the disease symptomatically and the effects are usually short-term. Thus, there is a need to look at alternatives AD therapies. Mid-life hypertension has not only been recognised as a risk factor for AD, but its relation with AD has also been well established. Thus, antihypertensives are postulated to be beneficial in managing AD. This literature review aims to shed some light on the potential of repurposing antihypertensives to treat AD, considering recent updates. Four classes of antihypertensives, as well as their potential limitations and future prospects in being utilised as AD therapeutics are discussed in this review.

Keywords:

Drug repurposing, Alzheimer's disease, anti-hypertensive, calcium channel blockers, acetylcholinesterase inhibitors, beta-blockers

Affiliation:

Monash University, School of Science, Jalan Lagoon Selatan, Bandar Sunway, 47500, Monash University, School of Science, Jalan Lagoon Selatan



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