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Nanoparticles as a Tool for Broadening Antifungal Activities

Author(s):

Daniele Fernanda Renzi, Laís de Almeida Campos, Eduardo Hösel Miranda, Rubiana Mara Mainardes, Wolf-Rainer Abraham, Diana Fortkamp Grigoletto and Najeh Maissar Khalil*   Pages 1 - 33 ( 33 )

Abstract:


The Fungal infections are diseases that are considered neglected although their infection rates have increased worldwide in the last decades. Thus, since the antifungal arsenal is restricted and many strains have shown resistance new therapeutic alternatives are necessary. Nanoparticles are considered important alternatives to promote drug delivery. In this sense, the objective of the present study was to evaluate the contributions of newly developed nanoparticles to the treatment of fungal infections. Studies have shown that nanoparticles generally improve the biopharmaceutical and pharmacokinetic characteristics of antifungals, which is reflected in a greater pharmacodynamic potential and lower toxicity, as well as the possibility of prolonged action. It also offers the proposition of new routes of administration. Nanotechnology is known to contribute to a new drug delivery system, not only for the control of infectious diseases, but for various other diseases as well. In recent years, several studies have emphasized its application in infectious diseases, presenting better alternatives for the treatment of fungal infections.

Keywords:

azoles, echinocandins, fungal infection, nanotechnology, polyenes.

Affiliation:

Pharmaceutical Nanotechnology Laboratory. Universidade Estadual do Centro-Oeste. Alameda Élio Antonio Dalla Vecchia, 838 - CEP 85040-167, Guarapuava-PR, Pharmaceutical Nanotechnology Laboratory. Universidade Estadual do Centro-Oeste. Alameda Élio Antonio Dalla Vecchia, 838 - CEP 85040-167, Guarapuava-PR, Pharmaceutical Nanotechnology Laboratory. Universidade Estadual do Centro-Oeste. Alameda Élio Antonio Dalla Vecchia, 838 - CEP 85040-167, Guarapuava-PR, Pharmaceutical Nanotechnology Laboratory. Universidade Estadual do Centro-Oeste. Alameda Élio Antonio Dalla Vecchia, 838 - CEP 85040-167, Guarapuava-PR, Helmholtz Center for Infection Research, Chemical Microbiology, Inhoffenstraße 7, 38124 Braunschweig, Pharmaceutical Nanotechnology Laboratory. Universidade Estadual do Centro-Oeste. Alameda Élio Antonio Dalla Vecchia, 838 - CEP 85040-167, Guarapuava-PR, Pharmaceutical Nanotechnology Laboratory. Universidade Estadual do Centro-Oeste. Alameda Élio Antonio Dalla Vecchia, 838 - CEP 85040-167, Guarapuava-PR



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