G. Portella, C. Passaro and P. Chieffi Pages 482 - 496 ( 15 )
Aurora B is a serine-threonine kinase belonging to the highly conserved Aurora family of mitotic kinases. Aurora B is a chromosomal passenger protein involved in chromosome segregation, spindle-checkpoint, and cytokinesis. Alteration of each of these steps could induce aneuploidy, one of main features, and driving force of cancer progression. The overexpression of Aurora B has been observed in several tumor types, and has been linked with a poor prognosis of cancer patients. In this review we will focus on the role of Aurora B in cancer development, its role as a prognostic marker, and the clinical outcome of recently developed Aurora(s) inhibitors.
Aurora kinase,Aurora B,serine-threonine kinase,mitosis,cytokinesis,cancer,inhibitors,Prognostic Marker,Therapeutic Target,aneuploidy,centrosome,chromosome,Testis Zinc Finger Protein (Tzfp),anaphase-promoting complex,phosphorylation,Cromosomal Passenger Complex,kinetochores,prometaphase,Survivin,INner CENtromere Pro-tein (INCENP),Histone Kinase,Tetrahymena thermophila,S. pombe,Saccharomyces cerevisiae,Drosophila,C. elegans,Xenopus,Spindle Checkpoint Kinase,microtubule-depolymerizing kinesin MCAK,Mi-totic Centromere-Associated Kinesin,Benzimidazoles,Cytokinesis Kinase,carcinoma,mesothelioma,glioblastoma,oral cancer,malignant en-dometrium,hepatocellular carcinoma,testicular germ,thyroid,colon,prostate,neoplastic lesions,Aurora Inhibitors,HESPERADIN,indolinone,chronic mye-loid leukemia (CML),acute lymphocytic leukemia
, , Dipartimento di Medicina Sperimentale, Seconda Universita di Napoli, Via Costantinopoli, 16 (80138) Naples, Italy.