Y. Shan Shan, J. Zhang, Z. Liu, M. Wang and Y. Dong Pages 523 - 538 ( 16 )
Tubulin protein is one of several members of a small family of globular proteins. It offers a potential target for anticancer drug design and development. Combretastatin A-4 (CA-4) is a potent anticancer and antiangiogenesis natural substance isolated from Combretum caffrum. Modifications on the CA-4 structure have led to a great number of novel CA-4 derivatives as potent tubulin inhibitors and high cytotoxic anticancer agents is becoming an interesting field, leading to a breakthrough in the treatment of cancer. In this review, the recent developments of novel CA-4 derivatives via the modifications on the A- and B-ring and the double bond as anticancer agents are discussed.
Combretastatin A-4,Tubulin inhibitors,Anticancer,Antineoplastic Agents,Structure-Activity Relationships,antiangiogenesis,Combretum caffrum,chromo-somes,mitosis,microtu-bules,apoptosis,colchicine,vinca alka-loid domain,vinblastine,vincristine,Combretastatins,stilbenoid phenol,tubulin polymerization,chemotherapeutic,structure-activity relationship (SAR),human myelogenous leukaemia cell line,phosphate diesters,carcinoma,pinacolylboronate,boronic acid,Ethene Bridge,olefinic bridge,antineoplastic activity,hyperploid
, , , , Department of Pharmacy, The First Affiliated Hospital of Medical College, Xi'an Jiaotong University, Xi'an, Shaanxi Province, 710061, P.R. China.