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A Systematic Review of the Anti-inflammatory Effects of Gallium Compounds

Author(s):

Victor de Albuquerque Wanderley Sales*, Taysa Renata Ribeiro Timóteo, Natália Millena da Silva, Camila Gomes de Melo, Aline Silva Ferreira, Marcos Victor Gregório de Oliveira, Emerson de Oliveira Silva, Larissa Morgana dos Santos Mendes, Larissa Araújo Rolim and Pedro José Rolim Neto   Pages 1 - 16 ( 16 )

Abstract:


Background: Inflammation is an essential response provided by the immune system, ensuring the survival during microbial infection, tissue injury and other noxious conditions. However, prolonged inflammatory processes are often associated with severe side effects on health.

Objective: This systematic review aimed to provide the evidence in the literature of the pre-clinical and human anti-inflammatory activity of gallium compounds from 2000 to 2019 focused on elucidating the mechanisms involved in the inflammatory process.

Methods: Seven bibliographical databases were consulted (PubMed, Medline, ScienceDirect, Scopus, Springer, Web of Science, and EBSCOhost). The selection of appropriate publications and writing of this systematic review was based on the guidelines contained in the PRISMA statement. Moreover, the assessment of methodological quality of the selected studies was also performed.

Results: From a total of 3018 studies 16 were included in this paper based on our eligibility criteria, which showed promising and consistent results. Conclusion: Further research concerning specific inflammatory conditions is required.

Keywords:

Gallium composts, inflammation, pro-inflammatory mediators, regeneration, medicinal chemistry, Inorganic compounds.

Affiliation:

Laboratório de Tecnologia dos Medicamentos. Federal University of Pernambuco (UFPE), Recife-PE, Laboratório de Tecnologia dos Medicamentos. Federal University of Pernambuco (UFPE), Recife-PE, Laboratório de Tecnologia dos Medicamentos. Federal University of Pernambuco (UFPE), Recife-PE, Laboratório de Tecnologia dos Medicamentos. Federal University of Pernambuco (UFPE), Recife-PE, Laboratório de Tecnologia dos Medicamentos. Federal University of Pernambuco (UFPE), Recife-PE, Laboratório de Tecnologia dos Medicamentos. Federal University of Pernambuco (UFPE), Recife-PE, Laboratório de Tecnologia dos Medicamentos. Federal University of Pernambuco (UFPE), Recife-PE, Laboratório de Tecnologia dos Medicamentos. Federal University of Pernambuco (UFPE), Recife-PE, Central de Análise de Fármacos, Medicamentos e Alimentos. Federal University of Vale do São Francisco (UNIVASF), Petrolina-PE, Laboratório de Tecnologia dos Medicamentos. Federal University of Pernambuco (UFPE), Recife-PE



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