Submit Manuscript  

Article Details


The Correlation between Lipid Metabolism Disorders and Prostate Cancer

Author(s):

Justyna Dłubek, Jacek Rysz, Zbigniew Jabłonowski, Anna Gluba-Brzózka* and Beata Franczyk   Pages 1 - 14 ( 14 )

Abstract:


Prostate cancer is second most common cancer affecting male population all over the world. The existence of a correlation between lipid metabolism disorders and cancer of the prostate gland has been widely known for a long time. According to hypotheses, cholesterol may contribute to prostate cancer progression as a result of its participation as a signalling molecule in prostate growth and differentiation via numerous biologic mechanisms including Akt signalling and de novo steroidogenesis. The results of some studies suggest that increased cholesterol levels may be associated with higher risk of more aggressive course of disease. The aforementioned alterations in the synthesis of fatty acids are a unique feature of cancer and, therefore, it constitutes an attractive target for therapeutic intervention in the treatment of prostate cancer. Pharmacological or gene therapy aimed to reduce the activity of enzymes involved in de novo synthesis of fatty acids, FASN, ACLY (ATP citrate lyase) or SCD-1 (stearoyl-CoA desaturase) in particular, may result in cells growth arrest. Nevertheless, not all cancers are unequivocally associated with hypocholesterolaemia. It cannot be ruled out that the relationship between prostate cancer and lipid disorders is not a direct quantitative correlation between carcinogenesis and the amount of the circulating cholesterol. Perhaps the correspondence is more sophisticated and connected to the distribution of cholesterol fractions, or even sub-fractions of e.g. HDL cholesterol.

Keywords:

Prostate cancer, carcinogenesis, cholesterol levels, lipids disorders, metastasis, cells growth, gene therapy.

Affiliation:

Department of Nephrology, Hypertension and Family Medicine; Medical University of Lodz, Zeromskiego 113, 90-549 Lodz, Department of Nephrology, Hypertension and Family Medicine; Medical University of Lodz, Zeromskiego 113, 90-549 Lodz, Department of Urology; Medical University of Lodz, Zeromskiego 113, 90-549 Lodz, Department of Nephrology, Hypertension and Family Medicine; Medical University of Lodz, Zeromskiego 113, 90-549 Lodz, Department of Nephrology, Hypertension and Family Medicine; Medical University of Lodz, Zeromskiego 113, 90-549 Lodz



Read Full-Text article