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Functional Role of Glycosphingolipids in Cancer

Author(s):

Changping Zheng, Marco Terreni, Matthieu Sollogoub and Yongmin Zhang*   Pages 1 - 12 ( 12 )

Abstract:


Glycosphingolipids (GSLs) are ubiquitous components on animal cell membranes, and exposed on the outer surface. Various studies have demonstrated that they play key roles in cells proliferation, adhesion, motility and differentiation. Usually, the specific types of GSLs are expressed more highly in tumors than in normal tissues, which are known as tumorassociated antigens. It has been revealed that most tumor cells show altered GSLs patterns on their surface, abnormal GSLs signaling and biosynthesis, which together play a major role in tumor development. Tumor-associated GSL antigens have been used in the development of antitumor vaccines. It is no doubt that GSLs play a crucial role in tumor progression and would be a promising target for cancer treatment.

Keywords:

glycosphingolipids, tumor-associated antigens, GSL signaling, carbohydrates, medicinal chemistry, cancer

Affiliation:

Sorbonne Université, CNRS, Institut Parisien de Chimie Moléculaire (UMR 8232), 4 Place Jussieu, 75005 Paris, Drug Sciences Department, University of Pavia, Viale Taramelli 12, 27100 Pavia, Sorbonne Université, CNRS, Institut Parisien de Chimie Moléculaire (UMR 8232), 4 Place Jussieu, 75005 Paris, Sorbonne Université, CNRS, Institut Parisien de Chimie Moléculaire (UMR 8232), 4 Place Jussieu, 75005 Paris



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