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Current Study of Medicinal Chemistry for Treating Spinal Tuberculosis

Author(s):

Biao Wang, Yuhang Wang and Dingjun Hao*   Pages 1 - 12 ( 12 )

Abstract:


Tuberculosis, caused by Mycobacterium tuberculosis, is one of the oldest diseases in the world and is one of the top ten causes of death in the world, which ranking first mortality in infectious diseases, far beyond the frightening disease AIDS. Besides that, the spinal tuberculosis is the most common form of extrapulmonary tuberculosis, accounting for approximately 1 to 3 % of all tuberculosis cases, and accounting for 50% of musculoskeletal infections. However, the drugresistant situation of spinal tuberculosis is still challenging world widely. This situation directly lead the spinal tuberculosis has a high disability rate and is difficult to treat, which causes heavy burden to patients, families and society. Therefore, it has been one of the focuses of tuberculosis researchers and spine doctors. Considering that, in this review, we aim to overview the current studies that focused on the novel understanding in current spinal tuberculosis medicine usage and extensive explorations for treating this severe disease.

Keywords:

Tuberculosis, spinal, medicine, inflammation, diagnosis, treatment

Affiliation:

Department of Spine Surgery, Honghui Hospital, Xi’an Jiaotong University College of Medicine, Department of Spine Surgery, Xi’an Medical University, Department of Spine Surgery, Xi’an Medical University



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