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The Role of Cholesterol Homeostasis in Diabetic Kidney Disease

[ Vol. 28 , Issue. 36 ]

Author(s):

Xinyun Chen, Qinghua Yin, Liang Ma* and Ping Fu   Pages 7413 - 7426 ( 14 )

Abstract:


Considerable evidence has proved that disturbed cholesterol metabolism played a crucial role in diabetic kidney disease. Besides, massive cholesterol depositions were found in intrinsic renal cells of diabetic kidney disease patients and animal models, causing cytotoxicity and affecting renal function. Statins could alleviate cholesterol depositions, podocyte injury, and microalbuminuria of diabetic kidney disease. In this review, we summarized the process of disturbed cholesterol metabolism and discussed how it induced kidney dysfunction in diabetic kidney disease.

Keywords:

Cholesterol, diabetic kidney disease, SREBP2, LDLR, ABCA1, ABCG1.

Affiliation:

Kidney Research Institute, Division of Nephrology, West China Hospital of Sichuan University, Chengdu 610041, Kidney Research Institute, Division of Nephrology, West China Hospital of Sichuan University, Chengdu 610041, Kidney Research Institute, Division of Nephrology, West China Hospital of Sichuan University, Chengdu 610041, Kidney Research Institute, Division of Nephrology, West China Hospital of Sichuan University, Chengdu 610041



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