L. Yang, S. Wang, T. Tian and X. Zhou Pages 557 - 568 ( 12 )
Z-DNA, an active element in genome, has drawn intense interest in chemical and biological field. Its dynamic and transient state makes it challenging to target and regulate. Thus, stabilizing and inducing Z-DNA both in vitro and in vivo is essential, so far, much many efforts have been made in these aspects. However, Z-DNAs induction and stabilization are always performed in high salt condition and sequence-dependent, limited inducers or stabilizers have been achieved with breakthrough in the aspects of real physiological condition and sequence-independence. Herein, we give a review of some typical kinds of Z-DNA inducers and stabilizers, discussing their inducing or stabilizing condition, mechanism, structural relationship and their limitation as well, attempted to get some implication and guidance for Z-DNA inducer or stabilizer design.
Z-DNA,inducer,stabilizer,conformational transition,genome,physiological,mechanism,Nucleic acids,macromolecules,topologies
, , , State Key Laboratory of Virology and College of Chemical and Molecular Sciences, Wuhan University, Hubei, Wuhan 430072, P. R. of China.