The Chlorophyll Catabolite Pheophorbide a as a Photosensitizer for the Photodynamic Therapy

Author(s):

L. E. Xodo, V. Rapozzi, M. Zacchigna, S. Drioli and S. Zorzet   Pages 799 - 807 ( 9 )

Abstract:

Pheophorbide a is a clorophyll catabolite that recently has drawn the attention of several investigators for its potential in photodynamic therapy. In this review we summarize its photophysical properties, phototoxicity, cellular localization, biodistribution and PDT activity as a free or conjugated molecule.

Keywords:

Photodynamic therapy,Pheophorbide a,Photophysical parameters,Tissue distribution,Imaging,In vivo activity,clorophyll,phototoxicity,PDT activity,photochemical reaction

Affiliation:

, , , , Department of Medical and Biological Sciences, P.le Kolbe 4, School of Medicine, 33100 Udine, Italy.

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