M. Gallagher, A. Bakker, M.A. Yassa and C.E.L. Stark Pages 197 - 199 ( 3 )
Risk for Alzheimers disease escalates dramatically with increasing age in the later decades of life. It is widely recognized that a preclinical condition in which memory loss is greater than would be expected for a persons age, referred to as amnestic mild cognitive impairment, may offer the best opportunity for intervention to treat symptoms and modify disease progression. Here we discuss a basis for age-related memory impairment, first discovered in animal models and recently isolated in the medial temporal lobe system of man, that offers a novel entry point for restoring memory function with the possible benefit in slowing progression to Alzheimers disease.
Memory,mild cognitive impairment,hippocampus,dentate gyrus/CA3,pattern separation,pattern completion,animal models,neuroimaging
, , , Department of Psychological and Brain Science, Johns Hopkins University, Baltimore, MD 21218, USA.