Jianzhi Gong, Wenfang Xu and Jie Zhang Pages 113 - 122 ( 10 )
Influenza is a disease that deeply affects millions of people every year. There has not been any drug effective against all strains. Neuraminidase (NA) is the major surface glycoprotein of the influenza virus, which possesses critical enzymatic activity and has been considered as a suitable target for designing agents against influenza viruses. Here we review the structure and functions of this enzyme and touch upon the structureactivity relationship (SAR) of existing influenza neuraminidase inhibitors (NAIs).
Influenza virus,Neuraminidase,Structure,Functions,Neuraminidase inhibitors,Structure-activity relationship
, , Department of Medicinal Chemistry, School of Pharmaceutical Sciences, ShanDong University, 44,West Culture Road, 250012, Ji'nan, ShanDong, P.R.China.