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Subtype-Selective Dopamine Receptor Radioligands for PET Imaging: Current Status and Recent Developments

[ Vol. 19 , Issue. 23 ]

Author(s):

A. Banerjee and O. Prante   Pages 3957 - 3966 ( 10 )

Abstract:


This review presents a general overview of the subtype-selective dopamine receptor radioligands for in vivo imaging of dopamine receptor expression by positron emission tomography (PET). Besides the 11C- and 18F-labeled radioligands which are already in clinical use, a summary of subtype-selective radioligands which had been studied in vitro and in vivo is provided, which shines light onto the current status and recent developments in this field of radiopharmaceutical research.

Keywords:

Dopamine, D2, D3, D4, dopamine receptor, selectivity, subtype-selectivity, positron emission tomography, PET, radioligand, PET ligand, radiopharmaceutical, F-18, C-11

Affiliation:

, Laboratory of Molecular Imaging and Radiochemistry, Nuclear Medicine Clinic, Friedrich-Alexander University, Schwabachanlage 6, D-91054 Erlangen, Germany.



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