C.N. Kapanda, J.H. Poupaert and D.M. Lambert Pages 1824 - 1846 ( 23 )
Endocannabinoid hydrolases are nowadays increasingly considered as potential therapeutic targets for treating several pathological states. So far, numerous classes of endocannabinoid hydrolase inhibitors have been described. We herein review the medicinal chemistry of these inhibitors with a particular emphasis on the basis of their design, chemical structure, structure-activity relationships, and inhibition mechanisms.
Endocannabinoid hydrolases, inhibitors, design, chemical structures, inhibition mechanism, structure-activity relationships.
, , Medicinal Chemistry, Cannabinoid and Endocannabinoid Research Group. B1.73.10, Louvain Drug Research Institute (LDRI). Université catholique de Louvain. 73 avenue E. Mounier B-1200 Bruxelles, Belgium.