Cristiane M. Cazal, Kantima Choosang, Vanessa Gisele P. Severino, João B. Fernandes, Maria Fátima G. F. da Silva, Paulo C. Vieira, Maria S. J. Nascimento, Gabriela M. Almeida, M. Helena Vasconcelos, Pannee Pakkong and Madalena M. M. Pinto Pages 1582 - 1589 ( 8 )
Twenty six compounds (coumarins, flavonoids and alkaloids) were evaluated for their ability to inhibit the growth of three human tumor cell lines: breast adenocarcinoma (MCF-7), non-small cell lung cancer (NCI-H460) and melanoma (A375-C5). Three of them [3-hydroxyflavone (6), 2’-hydroxy-3,4,4’,5,6’-pentamethoxychalcone (11), Siderin (20)] were very potent in inhibiting all human tumor cell lines tested. The structure / activity relationship is discussed.
Alkaloids, coumarins, flavonoids, tumor cell lines growth inhibitor.
, , , , , , , , , , CEQUIMED-UP/CEQOFFUP – Centro de Estudos de Quimica, Medicinal, Faculdade de Farmacia, Universidade do Porto, Porto, Portugal, Departamento de Ciencias Quimicas, Laboratorio de Quimica Organica e Farmaceutica, Faculdade de Farmacia, Universidade do Porto, Porto, Portugal.