Y. Terasaki, Y. Liu, K. Hayakawa, L.D. Pham, E.H. Lo, X. Ji and K. Arai Pages 2035 - 2042 ( 8 )
The neurovascular unit is now well accepted as a conceptual framework for investigating the mechanisms of ischemic stroke. From a molecular and cellular perspective, three broad mechanisms may underlie stroke pathophysiology – excitotoxicity, oxidative stress and inflammation. To date, however, most investigations of these basic mechanisms have focused on neuronal responses. In this mini-review, we ask whether these mechanisms of excitotoxicity, oxidative stress and inflammation can also be examined in terms of non-neuronal interactions in the neurovascular unit, including the release of extracellular vesicles for cell-cell signaling.
Cell-cell interaction, extracellular vesicles, neuronal cell death, neuroprotection, neurovascular unit, stroke.
, , , , , , Neuroprotection Research Laboratory, Departments of Radiology and Neurology, Massachusetts General Hospital and Harvard Medical School, USA.