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Herb-Drug Interactions: An Evidence Based Approach

[ Vol. 11 , Issue. 11 ]


P. D. Coxeter, A. J. McLachlan, C. C. Duke and B. D. Roufogalis   Pages 1513 - 1525 ( 13 )


The increasing use of herbal medicinal products (HMPs) in the community where people are also receiving prescription medicines suggests that adverse herb-drug interactions may be of significant public health consequence. The evidence available to guide practitioners in decision making is complex and consists of a range of sources including adverse event database entries, spontaneous or case reports, in vivo and in vitro drug metabolism studies, and in vivo drug interaction studies in healthy subjects and patients. In the absence of further rigorous studies to assess the clinical significance of herb-drug interactions, an evidencebased appraisal of the current literature is essential to guide practitioners involved in patient care.


herb-drug interactions, pharmacokinetics, pharmacodynamics, hypericum perforatum, panax ginseng, ginkgobiloba, glycyrrhiza glabra


Faculty of Pharmacy,Building A15, The University of Sydney, NSW 2006, Australia

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