Review of Procedures Used for the Extraction of Anti-Cancer Compounds from Tropical Plants

Author(s):

Saurabh Pandey, Paul N. Shaw and Amitha K. Hewavitharana   Pages 314 - 326 ( 13 )

Abstract:

Tropical plants are important sources of anti-cancer lead molecules. According to the US National Cancer Institute, out of the 3000 plants identified as active against cancer using in vitro studies, 70% are of tropical origin. The extraction of bioactive compounds from the plant materials is a fundamental step whose efficiency is critical for the success of drug discovery efforts. There has been no review published of the extraction procedures of anti-cancer compounds from tropical plants and hence the following is a critical evaluation of such procedures undertaken prior to the use of these compounds in cancer cell line studies, during the last five years. It presents a comprehensive analysis of all approaches taken to extract anti-cancer compounds from various tropical plants. (Databases searched were PubMed, SciFinder, Web of Knowledge, Scopus, Embase and Google Scholar).

Keywords:

Anti-cancer, bio actives, drug discovery, extraction, tropical plants.

Affiliation:

, , School of Pharmacy, The University of Queensland, Brisbane, Australia.

Graphical Abstract:

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