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Article Details


Gene Regulation in Cancer Gene Therapy Strategies

[ Vol. 10 , Issue. 20 ]

Author(s):

Ian Scanlon, Panos Lehouritis, Ion Niculescu-Duvaz, Richard Marais and Caroline J. Springer   Pages 2175 - 2184 ( 10 )

Abstract:


Regulation of expression in gene therapy is considered to be a very desirable goal, preventing toxic effects and improving biological efficacy. A variety of systems have been reported in an ever widening range of applications, this paper describes these systems with specific reference to cancer gene therapy.

Keywords:

transcriptional control, regulated expression, gdept, suicide gene

Affiliation:

Cancer Research UK Centre for Cancer Therapeutics at the Institute of Cancer Research, 15Cotswold Road, Sutton, Surrey, SM2 5NG; UK



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