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The Chemistry and Biochemistry of Spiraea japonica Complex

[ Vol. 10 , Issue. 21 ]


Xiaojiang Hao, Yuemao Shen, Ling Li and Hongping He   Pages 2253 - 2263 ( 11 )


The characteristic components of Spiraea japonica complex, which consists of seven varieties, are the hetisine- and atisine-type diterpene alkaloids, and the atisanetype diterpenes. From this complex, 20 hetisines, 37 atisines and 7 diterpenes were isolated during 1964-2001, including the observations of the isomerization of spiraea diterpene alkaloids having the oxazolidine ring and the interconversion of the oxazolidine rings, the configuration of the oxygen substitution at C-15 of the atisinetype alkaloids, and the interconversion relationship between the two main subtypes of the hetisine-type alkaloids. The chemotaxonomy based on structures of the reported diterpene alkaloids were suggested. The studies on the anti-inflammation, anti-platelet aggregation and neuroprotective bioactivities of the alkaloids from S. japonica var. acuta were reviewed as well.


spiraea japonica, chemotaxonomy, hetisine, atisine, atisane, diterpenes, diterpene alkaloids, anti-inflammation, anti-platelet aggregation, neuroprotection


State Key Laboratory of Phytochemistry and Plant Resources in West China, Kuming Institute ofBotany, Chinese Academy of Sciences, Heilongtan, Kunming, Yunnan 650204, China.

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