Jouko J. Vepsalainen Pages 1201 - 1208 ( 8 )
Bisphosphonates (BP) are pyrophosphate analogs having a P-C-P backbone. The oral bioavailability of BPs is ca. 1%, due to high ionisation at physiological pH. Using the prodrug approach, oral absorption can be increased by masking one or more ionizable groups (clodronate, etidronate), or using a targeting carrier system (alendronate, pamitronate).
pyrohosphate analogs, bisphosphonate, clodronate, etidronate
Department of Chemistry, University of Kuopio, P.O.Box 1627, FIN-70211 Kuopio