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Bisphosphonate Prodrugs

[ Vol. 9 , Issue. 12 ]

Author(s):

Jouko J. Vepsalainen   Pages 1201 - 1208 ( 8 )

Abstract:


Bisphosphonates (BP) are pyrophosphate analogs having a P-C-P backbone. The oral bioavailability of BPs is ca. 1%, due to high ionisation at physiological pH. Using the prodrug approach, oral absorption can be increased by masking one or more ionizable groups (clodronate, etidronate), or using a targeting carrier system (alendronate, pamitronate).

Keywords:

pyrohosphate analogs, bisphosphonate, clodronate, etidronate

Affiliation:

Department of Chemistry, University of Kuopio, P.O.Box 1627, FIN-70211 Kuopio



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