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Recent Developments on Ketolides and Macrolides

[ Vol. 8 , Issue. 14 ]

Author(s):

Yong-Jin Wu and Wei-Guo Su   Pages 1727 - 1758 ( 32 )

Abstract:


Recent semi-synthetic studies of erythromycin A culminated in the discovery of two ketolide drug candidates, HMR-3647 and ABT-773, for the treatment of community-acquired bacterial infections caused by both macrolide- and β-lactam-susceptible and -resistant S. pneumoniae, gram negative bacteria, and intracellular atypical pathogens. The discovery of ketolides has rekindled interest in macrolides, and recent efforts have also led to a novel class of 4”-carbamates with activity against macrolide-resistant organisms. This review is an account of recent developments on ketolides and macrolides in terms of both chemistry and antibacterial activity.

, Recent, Developments, on, Ketolides, and, Macrolides

Affiliation:

Bristol-Myers Squibb Pharmaceutical Research Institute, 5 Research Parkway, Wallingford, CT 06492-7660, USA.



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