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The 2-Chlorotrityl Resin a Worthy Addition to the Medicinal Chemists Toolbox

[ Vol. 8 , Issue. 6 ]


William J. Hoekstra   Pages 715 - 719 ( 5 )


The polystyrene-based 2-chlorotrityl resin was originally used in the synthesis of peptides using an Fmoc-amino acid(slash)carboxyl-linked protocol. While traditionally employed to prepare a number of biologically active peptides, the resin has received increasing attention as a support for the synthesis of pseudopeptide and non-peptide molecules recently. This review focuses on 2-chlorotrityl resin-supported synthesis of small molecules that collectively display a broad range of biological activities.


The 2-Chlorotrityl Resin, Polystyrene-based 2-chlorotrityl resin, Synthesis of peptide, Anti-infective agents, Enzyme inhibitors, Nuclear Receptor Modulators


Discovery Research Chemistry, Glaxo Smith Kline, North Carolina, USA

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