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New Chemical and Biological Aspects of S-Nitrosothiols

[ Vol. 7 , Issue. 8 ]

Author(s):

K. Wang, W. Zhang, M. Xian, Y. C. Hou, X. C Chen, J. P. Cheng and P. G. Wang   Pages 821 - 834 ( 14 )

Abstract:


Nitric oxide (NO) possesses many physiological effects and S-nitrosothiols have been identified in a variety of tissues exhibiting many NO-like activities. This review focuses on the latest discoveries pertaining to the biological functions of S-nitrosothiols and the recent research progress in the chemical properties and biomedical applications of RSNOs.

Keywords:

S nitrosothiols, nitric oxide NO, RSNOs, superoxide catalzed RSNO, blood flow regulation, apotosis, platelet neutrophil interaactions, perinatal circulatory transition, S Nitroso 1 thiolsugars, TGSNO, S nitrosopeptides, Drug SNO conjugates, adrenergic receptor, Cu Zn superoxide dismutase, cardiac calcium release channel, cyclic nucleotide gated channel, interleukin converting enzyme, inducible nitric oxide synthase, xanthine oxidase, s Nitrosohemoglobin, disulfide, s Nitrosothiol, thiyl radical, glucopyranose

Affiliation:

Department of Chemistry, Wayne State University, Detroit, MI 48202, USA



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