Bioisosterism: A Useful Strategy for Molecular Modification and Drug Design

Author(s):

Lidia Moreira Lima and Eliezer J. Barreiro   Pages 23 - 49 ( 27 )

Abstract:

This review aim to demonstrate the role of bioisosterism in rational drug design as well as in the molecular modification and optimization process aiming to improve pharmacodynamic and pharmacokinetic properties of lead compounds.

Keywords:

lead compound,isosterism,antagonist,pharmacodynamic,pharmacokinetic,hplc,prostaglandin-h synthase-2 (pghs-

Affiliation:

, Laboratorio de Avaliacao e Sintese de Substancias Bioativas (LASSBio), Faculdade de Farmacia, Universidade Federal do Rio de Janeiro. CCS, Cidade Universitaria, CP 68.006, 21944-190, Rio de Janeiro, R.J., Brazil.

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