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Catalytic Activity of Certain Antibodies as a Potential Tool for Drug Synthesis and for Directed Prodrug Therapies

[ Vol. 15 , Issue. 16 ]

Author(s):

T. Wojcik and K. Kiec-Kononowicz   Pages 1606 - 1615 ( 10 )

Abstract:


Catalytic activity of certain antibodies was proposed by Linus Pauling for the very first time more than six decades ago. Since then few examples of catalytic antibodies (abzymes) were found in human organism. From late 80s many synthetic abzymes were obtained after immunization by Transition State Analogs (TSA). Another approach is based on functional mimicry of antibody to an active site of an enzyme. Detection of an abzymatic activity requires special immunoassays. This unique strategy can be employed for new methods of drug synthesis, as well as for in vivo therapies. Catalytic antibodies seem to be a promising tool for therapeutic purposes, because of their specifity and stereoselectivity.

Keywords:

Catalytic antibodies, abzymes, transition state analogs, antibody-directed abzyme prodrug therapy

Affiliation:

Department of Technology and Biotechnology of Drugs, Medical College, Jagiellonian University, 9, 30-688 Krakow, Poland.



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