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Pharmacological Implications of MMP-9 Inhibition by ACE Inhibitors

[ Vol. 16 , Issue. 11 ]

Author(s):

Daisuke Yamamoto and Shinji Takai   Pages 1349 - 1354 ( 6 )

Abstract:


Matrix metalloproteinase-9 (MMP-9) plays an important role in the onset and prognosis of myocardial infarction. Targets of angiotensin converting enzyme (ACE) inhibitors might include not only ACE but also MMP-9, and ACE seems to be closely associated with complications of hypertension such as cardiovascular remodeling whereas MMP-9 is closely related to coronary diseases. We postulate that ACE inhibitors prevent coronary diseases via direct MMP-9 inhibition and could interact with the MMP-9 active sites using specific modes similar to those used for the ACE active sites. Research of the molecular interaction between MMP-9 active sites and ACE inhibitors appears to be an important key in the development of effective MMP-9 inhibitors for cardiovascular protection.

Keywords:

Matrix metalloproteinase-9, angiotensin converting enzyme inhibitor, angiotensin II receptor blocker, myocardial infarction, cardiovascular protection, coronary diseases, molecular interaction, inhibitory specificity

Affiliation:

Biomedical Computation Center, Osaka Medical College, 2-7 Daigakuchou, Takatuski, Osaka 569- 8686, Japan.



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