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Natural Polyphenols that Display Anticancer Properties through Inhibition of Kinase Activity

[ Vol. 17 , Issue. 9 ]

Author(s):

D. Lamoral-Theys, L. Pottier, F. Dufrasne, J. Neve, J. Dubois, A. Kornienko, R. Kiss and L. Ingrassia   Pages 812 - 825 ( 14 )

Abstract:


Over eleven hundred publications reporting anticancer activities of polyphenols have appeared in the peerreviewed literature. In addition, a search of the PubMed database using “polyphenols ” cancer “ review” as keywords produced over 320 hits for review articles (July 2009). Polyphenol anticancer activities include, among others, anti-oxidative, pro-apoptotic, DNA damaging, anti-angiogenic, and immunostimulatory effects. Targeting specific protein kinases to combat cancer represents a major focus of oncology research within the so-called targeted therapy approach. An exhaustive search of the PubMed database (July 2009) using “polyphenols - cancer - kinases” as keywords resulted in more than 130 hits, half of them having been published within the past five years. Furthermore, the PubMed database contains 25 reviews on the subject of anti-kinase activity of some specific polyphenols, including mainly curcumin and the green tea polyphenol (-)-epigallocatechin 3-gallate (EGCG). However, no attempt has been made yet to review this area of research in a comprehensive, general manner. The current review therefore aims to highlight those anticancer polyphenols that target specific kinases in various types of cancer. The present review also provides an in-depth analysis of polyphenol structure- activity relationships in relation to their anticancer activities and specific kinase targeting. Lastly, a number of polyphenols are identified as potential antitumor agents that could be used to combat biologically aggressive cancers, including metastasizing cancers, through the targeting of specific kinases.

, Natural, Polyphenols, that, Display, Anticancer, Properties, through, Inhibition, of, Kinase, Activity

Affiliation:

Laboratoire de Toxicologie - Institut de Pharmacie, Universite Libre de Bruxelles (ULB), Campus de la Plaine - CP205/1 - Boulevard du Triomphe, 1050 Brussels, Belgium.



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