Milos Hricovini Pages 2565 - 2583 ( 19 )
Structural diversity of carbohydrates plays a crucial role in their large variety of roles in biological systems. This paper focuses on aspects of structure and biological functions of three classes of carbohydrates, N-linked oligosaccharides, blood group oligosaccharides and glycosaminoglycans. Conformations and dynamics in solution, as well as structure of protein-carbohydrate complexes are discussed. A short overview also describes theoretical and experimental methodologies that are used in current glycobiological research, particularly high-resolution NMR spectroscopy, X-ray crystallography and methods of computational chemistry.
NMR spectroscopy,crystallography,oligosaccharides,carbohydrates
Institute of Chemistry, Slovak Academy of Sciences,845 38 Bratislava, Slovakia.