Submit Manuscript  

Article Details


Sequence Recognition of DNA by Lexitropsins

[ Vol. 8 , Issue. 5 ]

Author(s):

David S. Goodsell   Pages 509 - 516 ( 8 )

Abstract:


Lexitropsins are modular polyamide molecules that are designed to “read” the base sequence of DNA. Lexitropsins constructed of three types of subunits-- pyrrole, imidazole and hydroxypyrrole--allow full recognition of DNA base sequences. Structural studies have revealed the atomic basis of this specificity. Theoretical studies have explored the effectiveness of lexitropsins in targeting a given sequence within a genome, and have been used to analyze and improve lexitropsin design.

, Sequence, Recognition, of, DNA, by, Lexitropsins

Affiliation:

Department of Molecular Biology,The Scripps Research Institute, La Jolla, CA 92037 U.S.A.



Read Full-Text article