Synthesis and Cytotoxicity of Two Active Metabolites of Larotaxel

Author(s):

Jianwei Li, Anping Li, Minghua Li, Yufeng Qiao and Hui Zhang   Pages 875 - 880 ( 6 )

Abstract:

Two epimeric metabolites of Larotaxel were synthesized in eight steps from 10-DAB III as a commercial material and their structures were characterized using NMR and MS spectral data. The cytotoxicity of two metabolites was performed on breast cancer cell lines MCF-7, MX-1 and MDA-MB-231. It is remarkable that both of these two desired taxanes showed great potent cytotoxic effect.

Keywords:

Larotaxel, taxanes, synthesis, MCF-7, cytotoxicity, breast cancer.

Affiliation:

, , , , Department of Technology, Shanxi Zhendong Pharmaceutical Co., Ltd., Changzhi, 047100, China.

Graphical Abstract:

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