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Analysis of Molecular Targets of Mycobacterium tuberculosis by Analytical Ultracentrifugation

[ Vol. 18 , Issue. 9 ]

Author(s):

J. C. Borges and C. H.I. Ramos   Pages 1276 - 1285 ( 10 )

Abstract:


The interest in analytical ultracentrifugation (AUC) to analyze protein structural parameters and interactions has increased in the past decades as a result of several developments on new generation instrumentation and data analysis tools. In this article, we review AUC principles and applications to study proteins, emphasizing molecular targets of Mycobacterium tuberculosis.

Keywords:

Analytical ultracentrifugation, protein folding, Mycobacterium tuberculosis, protein structure-function, anti-tuberculosis agents, high centrifugal force, hydrodynamic parameters, sedimentation, colloids, macromolecules

Affiliation:

Institute of Chemistry of Sao Carlos,University of Sao Paulo-USP, Sao Carlos, SP, 13560-970, Brazil.



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