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A Review on Biological Activities and Chemical Synthesis of Hydrazide Derivatives

[ Vol. 19 , Issue. 4 ]

Author(s):

R. Narang, B. Narasimhan and S. Sharma   Pages 569 - 612 ( 44 )

Abstract:


There has been considerable interest in the development of novel compounds with anticonvulsant, antioxidant, hormone antagonist, analgesic, anti-inflammatory, antiplatelet, antimalarial, antimicrobial, antimycobacterial, antitumoral, vasodilator, antiviral and anti-trypanosomal activities. Hydrazones possessing an azometine -NHN=CH- proton constitute an important class of compounds for new drug development. Therefore, many researchers have synthesized these compounds as target structures and evaluated their biological activities. These observations have been guiding for the development of new hydrazide derivatives that possess varied biological activities.

Keywords:

Biological activities, Antimicrobial, Antiviral, Antimycobacterial, Anti-inflammatory, Analgesic, Antioxidant, Anticancer, Antimalarial, Antiarthritis, Anti-trypnosomal, Diuretic, Hydrazide, Hydrazone, Synthesis

Affiliation:

Faculty of Pharmaceutical Sciences, Maharshi Dayanand University, Rohtak 124001, India.



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