Diogo Matias, Patrícia Rijo and Catarina Pinto Reis Pages 568 - 589 ( 22 )
Natural products have been frequently used as sources of clinical useful pharmaceuticals. However, some intrinsic characteristics of the natural drugs have limited their use, namely their solubility and chemical stability in physiologic mediums. Innovative drug delivery systems may help overcome such limitations, thus providing more effective administration of natural products. Phytosome (Indena SPA, Italy) is one of the most exciting recent delivery technologies that improves the oral bioavailability of the phytopharmaceuticals by their inclusion in equimolar complexes with dietary phospholipids with vesicular shape in aqueous environments. The purpose of this review is to characterize the state of the art of the phytosome as drug delivery system of natural products, including a discussion of the natural drug-phospholipid complex interactions, mechanisms of oral and topical delivery, methods of preparation and phytosome recent applications and patents in the 2006-2016 period.
Phytosome, phyto-phospholipidic complex, natural compounds, innovative drug delivery systems, preparation and characterization techniques, clinical and nutritional uses.
CBiOS, Research Center for Biosciences & Health Technologies, Universidade Lusófona, Campo Grande 376, 1749-024 Lisboa, CBiOS, Research Center for Biosciences & Health Technologies, Universidade Lusófona, Campo Grande 376, 1749-024 Lisboa, Escola de Ciências e Tecnologias da Saúde, Universidade Lusófona, Campo Grande, 376, 1749-024 Lisboa