Maikel P. Peppelenbosch*, Gwenny M. Fuhler, Auke P. Verhaar and Luc J.W. van der Laan* Pages 928 - 936 ( 9 )
Background: The body of biomedical literature on Vitamin D effector mechanisms in gastrointestinal biology and pathophysiology is rapidly expanding. Accordingly, new possibilities of vitamin D biology-based therapeutical intervention in gastroenterological disease are being identified. However, the literature lacks a concise review on these developments, hampering comprehension of the possibilities involved for many in the community.
Results: Genetic vitamin D receptor (VDR) polymorphisms and other VDR biology regulation are involved in predisposition to gastrointestinal cancers and might allow tailored strategies for managing those individuals especially at risk, e.g. through vitamin D supplementation. Likewise, modulation of Hedgehog signaling by vitamin D analogues may have promise in combating gastrointestinal cancers or improving barrier function in IBD, but shortage in vitamin D levels may also influence inflammatory conditions of the gut through direct interaction with the mucosal immune system. Evidence justifying population-wide monitoring for vitamin D status is accumulating. Conclusion: There is kaleidoscopic interaction of vitamin D biology with many aspects of gastrointestinal tract biology. Vitamin D appears an attractive target for personalized approaches like precision and P4 medicine.Digestive tract physiology, kaleidoscopic, gastrointestinal, pathophysiology, Vitamin D, VDR.
Department of Gasteroenterology and Hepatology, Erasmus MC - University Medical Center Rotterdam's Gravendijkwal 230, NL-3015 CE Rotterdam, Department of Gasteroenterology and Hepatology, Erasmus MC - University Medical Center Rotterdam's Gravendijkwal 230, NL-3015 CE Rotterdam, Department of Gasteroenterology and Hepatology, Erasmus MC - University Medical Center Rotterdam's Gravendijkwal 230, NL-3015 CE Rotterdam, Department of Surgery, Erasmus MC - University Medical Center Rotterdam’s Gravendijkwal 230, NL-3015 CE Rotterdam