Juan M. Salas , Ana B. Caballero *, Ginés M. Esteban-Parra and José M. Méndez-Arriaga Pages 2796 - 2806 ( 11 )
Since their first synthesis back in the early 20th century, 1,2,4-triazolo[1,5- a]pyrimidines have aroused increasing interest in very diverse areas ranging from chemotherapy to agriculture or even photography. Their similarity to purines confers a potential bioactivity and this feature has been wisely exploited for therapeutic use, including antifungal, antipyretic, analgesic, antiinflammatory, antitumoral and antiparasitic properties. In this review, we focus on the compounds that these nitrogen heterocycles form with metal ions and their antiparasitic activity and therapeutic potential against two neglected diseases of tropical prevalence, leishmaniasis and Chagas disease.
Triazolopyrimidine, metal complexes, Leishmania, Trypanosoma cruzi, leishmaniasis, Chagas disease, neglected tropical diseases.
Department of Inorganic Chemistry, University of Granada, Avda. Severo Ochoa s/n, 18071 Granada, Department of Inorganic and Organic Chemistry (Inorganic Chemistry Section), University of Barcelona, Martí i Franquès 1–11, 08028 Barcelona, Department of Inorganic Chemistry, University of Granada, Avda. Severo Ochoa s/n, 18071 Granada, Department of Inorganic Chemistry, University of Granada, Avda. Severo Ochoa s/n, 18071 Granada