Tarik Smani*, Isabel Gallardo-Castillo, Javier Ávila-Médina, Manuel F. Jimenez-Navarro, Antonio Ordoñez and Abdelkrim Hmadcha Pages 4166 - 4177 ( 12 )
The pathophysiology linking diabetes and cardiovascular disease (CVD) is complex and multifactorial. The specific type of cardiomyopathy associated with diabetes, known as diabetic cardiomyopathy (DCM), is recognized as asymptomatic progression of structural and functional remodeling in the heart of diabetic patients in the absence of coronary atherosclerosis and hypertension. In other words, the presence of heart disease specifically in diabetic patients is also known as diabetic heart disease. This article reviews the impact of diabetes in heart and vascular beds focusing on molecular mechanisms involving the oxidative stress, the inflammation, the endothelium dysfunction and the alteration of the homeostasis of calcium, among others mechanisms. Understanding these mechanisms will help identify and treat CVD in patients with diabetes, as well as to plan efficient strategies to mitigate DCM impact in those patients.
Cardiovascular disease, diabetes, diabetic cardiomyopathy, calcium homeostasis, oxidative stress, endothelial dysfunction.
Group of Cardiovascular Physiopathology, Institute of Biomedicine of Seville-IBiS, HUVR/University of Seville/CSIC, Seville, Department of Stomatology, School of Dentistry, University of Seville, Seville, Group of Cardiovascular Physiopathology, Institute of Biomedicine of Seville-IBiS, HUVR/University of Seville/CSIC, Seville, UGC del Corazon, Instituto de Biomedicina de Malaga (IBIMA), Hospital Clínico Universitario Virgen de la Victoria, Universidad de Malaga, Malaga, Group of Cardiovascular Physiopathology, Institute of Biomedicine of Seville-IBiS, HUVR/University of Seville/CSIC, Seville, Department of Regeneration and Cell Therapy, Andalusian Center for Molecular Biology and Regenerative Medicine (CABIMER), Unversity of Pablo de Olavide- University of Seville-CSIC, Seville