Marinos Kosmopoulos, Anthos Christofides, Dimitrios Drekolias, Phaedon D. Zavras, Antonios N. Gargalionis and Christina Piperi* Pages 1954 - 1967 ( 14 )
Background: Glioma is a heterogeneous, highly complicated central nervous system (CNS) tumor with uncertain mechanism of initiation and progression, resulting in an unfavorable outcome. An extended network of cytokines is recognized as a major regulator of glioma pathogenesis, either promoting or inhibiting glioma progression based on their type and specificity. Interleukin-8 (IL-8) has been revealed as a critical regulator of CNS function and development with participation in many CNS disorders including gliomas.
Objective: The aim of the present review is to address the role of IL-8 in glioma pathogenesis focusing on the implicated molecular pathways as well as on its potential targeting for glioma therapy.
Methods and Results: PubMed-Medline, SCOPUS, and Google Scholar databases were searched for pre-clinical and clinical studies related to IL-8 implication in gliomagenesis and IL-8 targeting strategies for gliomas. Literature data indicate that IL-8 participates in glioma angiogenesis and cell migration and it can serve as a potential biomarker, for early diagnosis, follow-up and response to therapy.
Conclusion: Several promising approaches that target directly or indirectly IL-8 effects in gliomas are currently in progress while more-in-depth studies are needed to validate its biomarker role and elucidate the underlying molecular mechanisms.
Glioma, IL-8, angiogenesis, migration, therapy, CNS tumor, cytokines.
Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, 11527 Athens, Department of Biological Chemistry, Medical School, National and Kapodistrian University of Athens, 11527 Athens