Enrico Faggi, Santiago V. Luis and Ignacio Alfonso* Pages 4065 - 4097 ( 33 )
Pseudopeptides are privileged synthetic molecules built from the designed combination of peptide-like and abiotic artificial moieties. Consequently, they are benefited from the advantages of both families of chemical structures: modular synthesis, chemical and functional diversity, tailored three-dimensional structure, usually high stability in biological media and low non-specific toxicity. Accordingly, in the last years, these compounds have been used for different biomedical applications, ranging from bio-sensing, ion transport, the molecular recognition of biologically relevant species, drug delivery or gene transfection. This review highlights a selection of the most remarkable and recent advances in this field.
Pseudopeptides, sensing, transport, cation coordination, anion coordination, gene delivery.
Department of Biological Chemistry and Molecular Modelling, Institute of Advanced Chemistry of Catalonia, Consejo Superior de Investigaciones Cientificas, Barcelona, Department of Inorganic and Organic Chemistry, Universitat Jaume I, Castellon, Department of Biological Chemistry and Molecular Modelling, Institute of Advanced Chemistry of Catalonia, Consejo Superior de Investigaciones Cientificas, Barcelona